Prehospital acute care faces big challenges. New care processes and methods, as well as increasing demands on treatment outcome, safety, auditing and efficiency calls for co-operation and exchange of information between different stakeholders and systems, as well as advanced supporting ICT/eHealth. To cover the complete chain from incident to care at the right place, time and level, different interoperating components from various vendors are needed. Demands on standardization, holistic thinking, care knowledge, verification in authentic settings and openness in between all actors involved are therefore necessities for success. Furthermore the complexity regarding technology used, co-operating partners, legal issues etc. also have to be taken into account. Metis benefits from a unique regional situation when it comes to actors and knowledge domains in order to form a unique model for innovation and development of process supporting eHealth for prehospital acute care. The Metis collaboration model will enable sustainable development, growth and care development, and also strengthen Sweden’s frontline position as provider of tested and validated solutions, models and products targeting the entire field. Fundamental is new innovation promoting ways for active collaboration between industries, care providers and academy. This includes an “Open Innovation” influenced innovation arena named Metis Forum.